Calcium sensitivity and myofilament lattice structure in titin N2B KO mice
نویسندگان
چکیده
منابع مشابه
Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice.
Previous work suggests that titin-based passive tension is a factor in the Frank-Starling mechanism of the heart, by increasing length-dependent activation (LDA) through an increase in calcium sensitivity at long sarcomere length. We tested this hypothesis in a mouse model (N2B KO model) in which titin-based passive tension is elevated as a result of the excision of the N2B element, one of card...
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RATIONALE The giant protein titin plays key roles in myofilament assembly and determines the passive mechanical properties of the sarcomere. The cardiac titin molecule has 2 mayor elastic elements, the N2B and the PEVK region. Both have been suggested to determine the elastic properties of the heart with loss of function data only available for the N2B region. OBJECTIVE The purpose of this st...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2013
ISSN: 0003-9861
DOI: 10.1016/j.abb.2012.12.004